This Is Your Gut On Gluten

May 13th, 2016

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This Is Your Gut On Gluten

May is Celiac Disease Awareness Month. To support those with celiac disease AND anyone with a gluten sensitivity, I want to explain exactly what happens in your body when you eat gluten. This information can be very helpful for keeping yourself on track and explaining gluten’s impact on your health to your friends and family. Trust me when I tell you, even “just a little bit” of gluten can affect your health!

What is Gluten?

Gluten is a protein made up of the peptides gliadin and glutenin and it is found in many grains such as wheat, semolina, spelt, kamut, rye, and barley.

Gluten (from Latin, “glue”) is a protein that gives bread its airy and fluffy texture and dough its sticky texture. It’s also used as a stabilizing agent in many processed foods, such as salad dressings and mayonnaise. It’s in almost everything from beauty products to packaged foods to medications and supplements.

Why Is Gluten Getting Such a Bad Rap Now?

The prevalence of celiac and gluten sensitivity has increased significantly over the last 50 years. A 2009 study published in Gastroenterology showed that celiac disease has increased from one in 650 people to one in 120 people over the last 50 years. Some studies suggest that up to 30% of the population now suffers from gluten sensitivity. What’s worse, an estimated 99% of people with celiac or gluten sensitivity are never diagnosed; so more of us than ever are being negatively affected by gluten, but most of us don’t know it.

We’re no longer eating the wheat that our parents ate. In order to have the drought-resistant, bug-resistant, and faster growing wheat that we have today, we have hybridized the grain. It’s estimated that 5 percent of the proteins found in hybridized wheat are new proteins that were not found in either of the original wheat plants. These “new proteins” are part of the problem that has lead to increased systemic inflammation, widespread gluten intolerance, and higher rates of celiac.

Today’s wheat has also been deamidated, which allows it to be water soluble and capable of being mixed into virtually every kind of packaged food. This deamidation has been shown to produce a large immune response in many people. Lastly, in our modern fast-paced world with fast food at our fingertips, we are eating much more wheat than our ancestors ever did.

So, What Happens In Your Gut When You Eat Gluten?

Whether you are eating a sugary fried doughnut or organic 12-grain bread, the effects of gluten on your gut are the same. When your meal reaches your intestines, tissue transglutaminase (tTG), an enzyme produced in your intestinal wall, breaks down the gluten into its protein building blocks, gliadin and glutenin.

As these proteins make their way through your digestive system, your immune system in your gut, the gut-associated lymphoid tissue (GALT), reviews them for potentially harmful substances. In people who have no issues with gluten, the proteins are absorbed. In those with gluten sensitivity, the GALT identifies gliadin as a dangerous substance and produces antibodies to attack it. In celiac’s, these antibodies don’t just attack the gliadin, they attack the tTG as well, which is what originally broke down the gluten into its two parts.

This enzyme, tTG, has a number of jobs, including holding together the microvilli in our gut. Your body collects nutrients by absorbing them through the walls of your intestines, and the more surface area there is, the more they can absorb. Imagine trying to soak up a gallon of water with a paper towel versus a bath towel. Microvilli, which look like hairy fingers, exist in your intestines to increase the surface area and absorb nutrients.

When the antibodies your body produced to defend itself against gliadin attack your tTG, these microvilli can atrophy and erode, decreasing your ability to absorb nutrients and allowing the walls of your intestines to become leaky. This can manifest itself in digestive symptoms, including bloating, constipation, diarrhea, weight loss, fat malabsorption and malnutrition, such as iron deficiency or anemia, low vitamin D or even osteoporosis.This blunting of the microvilli is the hallmark of celiac disease, which is an autoimmune disease.

How does gluten cause intestinal permeability, a.k.a leaky gut?

Regulating intestinal permeability is one of the basic functions of the cells that line the intestinal wall. In sensitive people, gluten can cause the gut cells to release zonulin, a protein that can break apart the tight junctions holding your intestines together.

Once these tight junctions get broken apart, your gut is considered to be leaky. A leaky gut allows toxins, microbes, undigested food particles, and antibodies to escape from your intestines and travel throughout your body via your bloodstream. The antibodies that escape are the ones that your body produced to attack the gliadin in the first place.

What is the link between gluten, systemic inflammation, and autoimmune disease?

Unfortunately, these antibodies often confuse more than just tTG for gliadin, and end up attacking other organs and systems, from the skin to the thyroid to the brain. This is why gluten sensitivity is frequently paired with autoimmune conditions and why those with celiac disease are at risk of developing a second autoimmune disease. I would suggest that if you have an autoimmune disease you get tested for gluten sensitivity, and if you’re gluten sensitive, you should get screened for autoimmunity.

How to determine if you’re gluten sensitive?

The single best way to determine if you are gluten sensitive is to take it out of your diet for at least 30 days, then reintroduce it. Your body knows better than any test. If you feel significantly better without gluten or feel worse when you reintroduce it, then gluten is likely a problem for you, even if your lab tests are negative. Lab testing for both is available as well, however, there are some inherent problems with this testing. Check out my article, “How to Test for Gluten Sensitivity and Celiac Disease,” for more information regarding this or purchase my Guide to Gluten eCourse.

How to treat gluten sensitivity or celiac?

Eliminating 100 percent of gluten from your diet. Trace amounts of gluten from cross-contamination or medications can be enough to cause an immune reaction in your body.

When in doubt, go without. You may be saving your life or the life of someone you love.


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  • Bethany

    This is a great article! I love the way you thoroughly explain in terms we can all understand. I have Celiac disease and I have heard and read from a couple different sources (Gluten Free Summit) that all grains contain gliadin/gluten or proteins that look to the body like gluten, causing a cross-reaction and therefore all grains should be removed. I’m curious to know what you take is on this.

    • Yes, for many I recommend a Paleo diet or a grain free, lectin free diet. That is what I personally eat.

  • Dawn Lovisa

    Thank you! Wonderful article!

    • Dr. Amy Myers

      you’re so welcome

    • You’re so welcome!

  • Michele Conner

    I just made chicken nuggets with gluten free flour from the maker Bob’s Mill, and after eating it I feel bloated and my stomach hurts. EXACTLY how I feel after eating Gluten. Now what can cause that?
    2nd question: Do I need to be diagnosed for Celiac Disease? I know that gluten makes me sick but is Celiac disease more serious then just gluten sensitivity?

  • Rob Kidd
    • Honestly I think it’s a poorly designed study. Using whey as a placebo is meaningless, as whey is also a common allergen and actually cross-reacts with gluten. Most of my patients who can’t tolerate gluten also can’t tolerate whey.

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