Product Benefits

Physician Formulated

PHYSICIAN FORMULATED

3rd Party Tested

3RD PARTY TESTED

AIP Friendly

AIP FRIENDLY

GMP Compliant

GMP COMPLIANT

Gluten-free

GLUTEN-FREE

Non-Dairy

NON-DAIRY

Physician Formulated

PHYSICIAN FORMULATED

3rd Party Tested

3RD PARTY TESTED

AIP Friendly

AIP FRIENDLY

GMP Compliant

GMP COMPLIANT

Gluten-free

GLUTEN-FREE

Non-Dairy

NON-DAIRY

Why I Made This

“Histazyme works like a charm. Taking Histazyme up to 15 minutes before a meal can help break down ingested dietary histamine, thereby eliminating the histamine buildup and immune response and uncomfortable symptoms associated with it.†”

Signature image

Frequently Asked Questions

Will Histazyme help break down histamine in my bloodstream and nervous system?

The enzyme in Histazyme, diamine oxidase (DAO), does not absorb intestinally and therefore does not work systemically. Histazyme helps break down food-derived histamine only. This means that you can take it before meals to help break down histamine in the gut, but it will not exert its histamine digesting effects systemically or throughout the body.† 

Can Histazyme help with IgE or IgG immune response related to food allergies the way an antihistamine can?

Histazyme is not an “antihistamine,” which is a class of drugs regulated by the FDA. The enzyme in Histazyme, DAO, is not absorbed and does not have systemic activity. Because of this, Histazyme does not manage or address antibody-related or IgE-related food allergies. Histazyme is NOT INTENDED FOR AND IS NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease.

Where does the DAO enzyme in Histazyme come from?

The DAO enzyme in Histazyme is a porcine glandular extract. This means that if you are in any way allergic to pork, or avoid pork for spiritual or other reasons, you will want to avoid Histazyme as well. 

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The reviews posted on this site are solely the opinions of our customers and do not represent the views or opinions of AMMD. We do not control, edit, or alter the content of customer-submitted reviews.

4.6
Rated 4.6 out of 5 stars
Based on 216 reviews
Total 5 star reviews: 172 Total 4 star reviews: 25 Total 3 star reviews: 9 Total 2 star reviews: 2 Total 1 star reviews: 8
89%would recommend this product
Reviews Summary
Customers say this supplement helps them enjoy a wider variety of foods with fewer reactions. Many reviews mention improved dining experiences, with users able to eat previously problematic items. While most report positive results, some note experiencing adverse reactions. Common feedback includes its effectiveness for dietary flexibility, though several mention the high price point. Users appreciate the small, easy-to-swallow pills and report varying levels of relief. Some indicate taking it before meals works best, while others use it daily. A few reviews note no noticeable effects, but most describe positive experiences with regular use.
216 reviews
  • CJ
    Charleen J.
    Verified Buyer
    Yesterday
    Rated 5 out of 5 stars
    Amazing!!

    I have a tough time with high histamine foods. This is a life saver! As long as I take this right before I eat It reduces my reaction. Love it!!

    AM Profile picture for Amy Myers MD
    Amy Myers MD
    23 seconds ago

    Hi Charleen! We appreciate the review!

    We are glad to hear that the Histazyme is a life saver for you and that it helps reduces the reactions with high histamine foods!

    AMMD® Customer Success Team

  • ZL
    Zenda L.
    Verified Buyer
    1 month ago
    Rated 5 out of 5 stars
    Chronic hives

    Started my husband using these for chronic hives as all other resources were failing. After using for about 2 weeks his hives have been in remission. I honestly believe his body wasn’t creating the DAO enzyme and these helped build them up. Praying now they stay in remission.

  • LM
    Linda M.
    Verified Buyer
    3 months ago
    Rated 5 out of 5 stars
    Amazing!

    I’ve been suffering for years from what I was told was IBS. I followed the low FODMAP diet but it became increasingly difficult to find foods that didn’t upset my stomach. When I saw an email from you about histamine intolerance I immediately started doing some research and concluded that Histazyme was worth a try. From the first pill I took my stomach felt better. I’ve been able to eat so many more foods! I love this stuff!

  • CT
    Concetta T. P.
    Verified Buyer
    4 months ago
    Rated 5 out of 5 stars
    Good product

    I have serious histamine issue due to food intolerance and insensitivies. This is working......

  • TK
    Terri K.
    Verified Buyer
    4 months ago
    Rated 5 out of 5 stars
    DAO for histimine relief

    I have issues with histimine sontake this product to break down it. It works like a charm.