“Which supplements should I take?” was one of the most common questions asked by my patients with autoimmunity. And since autoimmune diseases are becoming more common all around the globe, it’s an issue of concern everywhere. Today I’ll cover the five supplements that I often recommended to my autoimmune patients.

As I explain in The Autoimmune Solution, if you are dealing with autoimmunity, the source of your condition is a glitch in your immune system. Environmental risk factors such as diet, a leaky gut, toxins, infections, and stress lead your immune system to attack your own tissues.

It could be your thyroid being attacked, or your joints under fire, or symptoms associated with your skin. No matter what particular organ or tissue is attacked, your immune system is doing the firing. By supporting rather than suppressing your immune system, you are able to eliminate symptoms and reverse your condition.

No matter the autoimmune condition these same five key supplements all work to optimize your immune system. When taken together, three of these supplements — glutathione, curcumin, and resveratrol — enhance one another’s effects, making them even more powerful!

You can watch and listen to this Facebook Live that describes the potentiation of these supplements.

To get your immune system in optimal condition, here are my top five supplements for autoimmunity.

1. Glutathione

The role of Glutathione is as your body’s primary detoxifier and it plays a crucial role in helping your immune system fight off infections. While it is concentrated in your liver, glutathione is also in every cell in your body. The three key amino acids in glutathione — cysteine, glycine, and glutamate — help bind free radicals and toxins. Then it can move them safely and effectively out of your system.

Your body produces some level of glutathione naturally. However, a poor diet, exposure to toxins, medications, stress, and illness deplete your levels or stop glutathione synthesis altogether. Glutathione deficiency factors into oxidative stress as well as triggering your body’s inflammatory response.

And we know that autoimmune diseases including rheumatoid arthritis, Crohn’s disease, and multiple sclerosis re often the result of chronic inflammation.1

Without enough glutathione, your body cannot properly detox. Toxins linger in your bloodstream or get stored in fat. This wreaks havoc on your immune system and sets you up for chronic illness.2

I recommend a glutathione supplement for those with autoimmunity, toxic mold, heavy metal overload, or general toxin exposure. It’s so powerful that I even recommend increasing glutathione levels to anyone who wants to reach peak optimal health. However, I tried a LOT of different types of glutathione, especially when I dealt with mold exposure. It is very challenging to get a form of glutathione that actually works!

Glutathione Sources

Intravenous (IV) glutathione supplementation is the gold standard. Yet it’s expensive and inconvenient. Oral glutathione supplementation is more readily available, however, it’s not commonly found in the liposomal or acetylated form. That means most will break down before your body can use them.

The “liposomal” form of glutathione is in a fat-soluble membrane that helps protect it from breaking down in the gut so it can effectively penetrate your cell walls. However, after working with thousands of patients, I recommend the “acetylated” form over all others. Your body easily absorbs it without breaking it down. Adding an acetyl group makes the glutathione molecule more stable and enhances its ability to cross the blood-brain barrier.3

The glutathione I offer is acetylated in nanotechnology, making it even more readily used by your body than other acetylated forms. The acetylation process and microcluster molecular structure ensure that it won’t break down before your body absorbs it so you can enjoy all the health benefits.

2. Curcumin

There’s a lot of hype around curcumin these days. And for good reason! Curcumin comes from a highly concentrated extract of turmeric. It plays a huge role in promoting a healthy inflammatory response, a healthy immune system, and healthy aging.

It can be can support a healthy inflammatory response, without gut-damaging side effects of NSAIDs such as aspirin and ibuprofen. It can positively impact the expression of genes that regulate systemic inflammation, which is a major factor in anyone with autoimmunity.4

Similar to glutathione, even high-grade curcumin supplements are not well absorbed and often metabolized by your liver before being utilized. That’s why I recommend a fat-soluble form of curcumin. Since curcumin naturally dissolves in fat, taking it in a fat-soluble form allows it to remain intact until it can actually be absorbed by your cells.

A micelle formula of liposomal curcumin is the world’s most absorbable form of curcumin. What is a micelle? It’s a fat pocket. My Liposomal Curcumin solves the problem of poor absorption by coating the curcumin with a thin layer of fat from medium-chain-triglyceride (MCT) oil.

Your intestinal lining readily absorbs the micelle “pocket” created by MCT oil which protects it from metabolism by your liver. This way, the potent, 500mg of naturally extracted curcumin per serving can travel freely throughout your body to the cells and tissues that need it the most.

3. Resveratrol

Resveratrol is the potent compound found in red wine. It’s known for its anti-aging benefits and its effect on metabolism.

Research has shown that resveratrol can support your body in slowing the progression of autoimmune disease symptoms.

Resveratrol is a powerful free radical scavenger that neutralizes unstable molecules that can damage your cells. These can trigger a leaky gut or even lead to premature aging.5 Resveratrol also helps modulate your immune system by regulating the activity of a kind of white blood cells called natural killer cells. This helps balance your immune response if your immune system is overactive or suppressed.6

Resveratrol may also benefit heart health, which is essential because people with autoimmunity are more susceptible to heart disease. In fact, one study shows that women aged 35 – 44 who have lupus are 50 times more likely to have a heart attack than other women of similar age.7

Resveratrol helps protect the innermost layer of your arteries called your endothelium, and increases your endothelial production of nitric oxide, supporting balanced blood pressure.

Unfortunately, red wine has sugar, alcohol, sulfites, and histamines. You can get all of the health effects of resveratrol without these by taking a resveratrol supplement.

4. Immune Booster

Your immune system uses proteins called immunoglobulins, or antibodies, to fight off bacteria and viruses. There are four types of immunoglobulins: IgA, IgE, IgG, IgM. They are the first line of defense in your gut, where nearly 80% of your immune system lives.

My autoimmune patients were often low in immunoglobulins. Many of them were surprised to learn this. That’s because they thought that if they have an autoimmune disease then their immune system is TOO strong. That’s why it’s attacking them.

In reality, the opposite is typically true. It’s when your immune system is overstressed that it attacks your own cells. Supporting your immune system, rather than suppressing it, is what’s important. That’s why I recommend my Immune Booster supplement for patients dealing with autoimmunity.

Immune Booster contains whey peptides from supercharged colostrum. Colostrum is a very special kind of milk produced only in the early stage of lactation. It offers concentrated amounts of all four immunoglobulins to support immune function and your body’s normal gut repair pathways. Immune Booster also helps you maintain a healthy inflammatory response in your intestinal tract and colon.

If you have an autoimmune disease, I recommend you take this supplement all the time. However, everyone can benefit from Immune Booster, especially during the winter months. Your immune system tends to be more vulnerable to seasonal illnesses.

5. L-Glutamine

The last supplement I recommend to everyone with autoimmunity is L-Glutamine. L-Glutamine is an amino acid that helps seal the tight junctions in your gut. Your gut cells naturally turn over every 48 hours, which is why it’s possible to repair your gut in 30 days following The Myers Way®. L-Glutamine works by speeding up that process and helping to restore your gut lining if you have a leaky gut.

Autoimmune Disease Supplements - Infographic - Amy Myers MD

As I lay out in my book, The Autoimmune Solution, repairing your gut is the first step to overcoming autoimmunity. Remember, nearly 80% of your immune system lives in your gut. Maintaining a healthy gut is key for anyone with an autoimmune condition. It’s why I always say the gut is the gateway to health!

In addition to promoting optimal gut health, L-Glutamine supplements support thyroid and immune system function. It also combats sugar cravings and supports healthy weight maintenance.

Ultimately, when you have an autoimmune disease, your best course of action is to support your immune system and help it do the work that will keep you healthy. There are many supplements available that could provide protection and relief to help you reverse your condition and take back your health. These are the top 5 supplements I recommend for autoimmune disease. These are just a starting point on your journey to health and wellness!

Article Sources

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756154/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756154/
  3. http://glutathionepathway.com/types-of-glutathione/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003001/
  5. https://science.sciencemag.org/content/339/6124/1216?sid=b369173a-02a4-4f5c-b693-4a1e4e870a4d
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748756/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394909/