Person taking probiotic supplement with water to support SIBO gut health and digestion

Table of Contents:

  1. The Role of Probiotics in Gut Health
  2. Can Probiotics Help SIBO?
  3. SIBO Probiotics to Avoid
  4. Which Probiotic Strains Work Best for SIBO
  5. How to Integrate Probiotics Into a SIBO Treatment Plan
  6. The Bottom Line on SIBO Probiotics
  7. FAQs

 

Probiotics are often thought of as the “secret sauce” that fixes all your digestive woes. It's true that probiotics can improve several digestive issues. However, some strains are well tolerated, while others may worsen gut conditions. Small intestinal bacterial overgrowth (SIBO) is one example where this can happen.

I often get asked this question: Can probiotics help SIBO or make it worse? The answer depends on the strain. Each strain supports different microbiomes throughout the body. Some probiotics are better for Candida overgrowth or Leaky Gut, while others can feed the overgrowth of SIBO.

The Role of Probiotics in Gut Health

Your gut microbiome functions as a living ecosystem. I often describe it as a rainforest of many different microorganisms living in harmony. When balanced, it supports digestion, immune function, and nutrient absorption. A healthy microbiome also helps regulate hormones and maintain the gut barrier. This is essential for preventing inflammation.

Many factors can disrupt this delicate balance. These include a poor diet or consuming the wrong types of foods, even when you think you’re being healthy. Also, chronic stress, environmental toxins, infections, and medications such as antibiotics play a big role. Over time, this disruption can lead to bacterial overgrowth.

Probiotics are often recommended to restore balance. This approach works in many cases. However, SIBO differs in that it can cause bacteria to grow in the wrong place.

Learn more about the critical role your gut plays in digestion, mental health, and stress management with Dr. Vincent Pedre on this episode of the Take Back Your Health™ podcast.

Can Probiotics Help SIBO?

The answer is Yes. The right probiotics can support SIBO recovery.

Research shows that certain strains may reduce bacterial overgrowth and improve symptoms:

  • Bacillus coagulans
    This strain supports immune function and may reduce hydrogen-dominant SIBO.(1) 
  • Bacillus subtilis
    This strain promotes the production of natural antimicrobial compounds. It also supports IgA levels and gut barrier repair.(2)
  • Lactobacillus reuteri
    This is a unique exception. Clinical research shows it may help reduce methane levels. This makes it beneficial in select cases.(3)
  • Saccharomyces boulardii
    This beneficial yeast supports gut balance. It may reduce bloating, abdominal pain, diarrhea, and hydrogen breath test levels.(4)

These strains work because they support balance without contributing to overgrowth in the small intestine.

SIBO Probiotics to Avoid

This is one of the most important sections to understand.

Many conventional probiotics contain lactobacillus and bifidobacterium strains. These bacteria are beneficial in the large intestine. In SIBO, they often overgrow in the small intestine.

When this happens, it can worsen symptoms and add more fuel to the fire.

Why certain probiotics may cause issues:

  • They colonize the small intestine instead of reaching the colon
  • They produce gas during fermentation
  • They contribute to bloating and discomfort

Many standard probiotics do not survive stomach acid. As a result, they may accumulate in the small intestine.

Signs your probiotic may be making SIBO worse:

If you notice these symptoms, reassess your probiotic.

Be cautious with marketing claims. Many products promote general gut health without listing specific strains. Always review the label and confirm third-party testing.

Which Probiotic Strains Work Best for SIBO

Soil-based probiotics are often the best choice for SIBO. These probiotics contain spore-forming bacteria. This structure allows them to survive stomach acid and reach the large intestine intact.

Historically, humans consumed these microbes from soil on fresh foods. Modern sanitation has reduced this exposure, increasing our need for supplementation. 

Benefits of soil-based probiotics:

  • Survive the digestive process
  • Do not colonize the small intestine
  • Support microbial diversity
  • Help restore balance safely

AMMD™’s Primal Earth Probiotic contains three targeted strains:

  • Bacillus clausii
  • Bacillus coagulans
  • Bacillus subtilis

These strains support gut balance without feeding overgrowth. This formula does not require refrigeration, making it ideal for travel and daily use.

How to Integrate Probiotics Into a SIBO Treatment Plan

I use a three-step approach to address SIBO:

3 steps to reverse SIBO showing diet changes to starve bacteria, antimicrobials to disrupt overgrowth, and probiotics to restore gut balance

1. Starve

Remove foods that feed bacterial overgrowth. Focus on nutrient-dense, AIP-compliant foods such as:

  • Grass-fed meats
  • Wild-caught fish
  • Non-starchy vegetables
  • Healthy fats such as olive oil and coconut oil

Avoid grains, dairy, legumes, refined sugar, and especially fermented foods. Fermented foods can add fuel to the fire and cause further overgrowth.

2. Disrupt

Target the overgrowth with antimicrobials. AMMD™’s SIBO Support Protocol includes Microb-Clear®, which contains herbal ingredients designed to support optimal microbial balance.

3. Balance

Rebuild a healthy microbiome. This is where the right probiotics play a key role.

Introduce a soil-based probiotic such as Primal Earth Probiotic during this phase. This helps restore balance without contributing to overgrowth.

You may also support gut repair with Leaky Gut Revive® which contains gut soothing ingredients such as L-glutamine, marshmallow root, and slippery elm. These ingredients support the integrity of the gut lining.

For a complete step-by-step plan, explore the SIBO Support Protocol, where you’ll find Microb-Clear®, Leaky Gut Revive®, and Primal Earth Probiotic included into the program. 

The Bottom Line on SIBO Probiotics

Not all probiotics are created equal. Some are beneficial for general gut health, while others cause more harm for conditions such as SIBO. The right strains can support healing. The wrong strains may worsen symptoms.

A targeted approach is essential. Soil-based probiotics such as Primal Earth offer a safe and effective way to restore balance. With the right plan, such as the SIBO Support Protocol, it can be managed by providing gut nourishment and improving your quality of life.

FAQs

  • What is the difference between soil-based probiotics and regular probiotics for SIBO?
    Soil-based probiotics contain spore-forming bacteria that are more resilient and less likely to colonize the small intestine. Traditional probiotics, such as Lactobacillus and Bifidobacterium strains, can sometimes overpopulate the small intestine in those with SIBO, making soil-based options a better-tolerated choice for some individuals.
  • Can taking the wrong probiotic actually cause small intestinal bacterial overgrowth to worsen?
    Yes. Certain probiotic strains can contribute to bacterial overgrowth in the small intestine, especially if gut motility is impaired. This may lead to increased bloating, gas, and discomfort, which is why selecting the right strains is important when managing SIBO.
  • Are there any Lactobacillus strains that are safe to take with SIBO?
    Some Lactobacillus strains may be better tolerated depending on the individual, but responses can vary. Lower-dose, targeted formulations are typically preferred, and it is often recommended to introduce them gradually while monitoring symptoms.
  • When in the SIBO treatment protocol should I start taking probiotics?
    Probiotics are often introduced after initial antimicrobial or treatment phases to help support gut balance and prevent recurrence. Timing can vary depending on your protocol, so it is important to align probiotic use with your overall treatment strategy.
  • How do I know if my probiotic is making my SIBO worse?
    If you experience increased bloating, gas, abdominal discomfort, or changes in bowel habits after starting a probiotic, it may not be the right fit for your current condition. Tracking symptoms and adjusting accordingly can help determine whether a probiotic is beneficial or contributing to issues.

Article Resources

  1. Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism. Shiwan Hu, Qiyou Ding, et al. Gut Microbes. 2023. Accessed on March 25, 2025.
  2. Evaluating the efficacy of probiotics on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study. AR Khalighi, MR Khalighi, et al. Indian Journal of Medical Research. 2014. Accessed on March 25, 2025. 
  3. Effect of Combined Live Probiotics Alleviating the Gastrointestinal Symptoms of Functional Bowel Disorders. Jin Shi, Feng Gao, et al. Gastroenterology Research and Practice. 2020. Accessed on March 25, 2025. 
  4. Effect of Lactobacillus reuteri (DSM 17938) on methane production in patients affected by functional constipation: a retrospective study. V Ojetti, C Petruzziello, et al. Eur Rev Med Pharmacol Sci. 2017. Accessed on March 25, 2025.
  5. Effectiveness of Saccharomyces boulardii and Metronidazole for Small Intestinal Bacterial Overgrowth in Systemic Sclerosis. Grettel García-Collinot, Eduardo Osiris, et al. Digestive Diseases and Sciences. 2020. Accessed on March 25, 2025.
Meet the Author

Amy Myers, MD

Dr. Myers is an accomplished, formally-trained physician who received her Doctorate of Medicine from Louisiana State University Health Science Center in 2005.
Along the way, she made it her mission to help those who've also been failed by the conventional medical system restore their own health and live their best lives.

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