“Which supplements for autoimmune disease should I take?” was one of the most common questions asked by my patients with autoimmunity. And since autoimmune diseases are becoming more common all around the globe, the best natural supplements for autoimmune disease is an issue of concern everywhere. Today I’ll cover the four autoimmune supplements that I often recommended to my patients, Glutathione, Curcumin, Resveratrol, and L-Glutamine. I’ll also explain how you can tackle autoimmunity from every angle using The Myers Way® Autoimmune Kit.

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Four Key Autoimmune Supplements

No matter the autoimmune condition, these four key autoimmune supplements all work together to support your immune system. When taken together as part of The Myers Way® Autoimmune Kit, these autoimmune supplements — glutathione, curcumin, l-glutamine, and resveratrol — enhance one another’s effects, making them even more powerful autoimmune natural treatments!

In this article, I’ll describe the top 4 physician-formulated autoimmune supplements I recommend to support a healthy immune response, especially when autoimmunity is a concern.

You can also check out my video on the best natural supplements for autoimmune disease below:

1. Glutathione

Glutathione plays a very important role in whole-body health. It is your body’s primary detoxifier and is crucial in helping to support optimal immune function. While it is concentrated in your liver, glutathione is also in every cell in your body. The three key amino acids in glutathione — cysteine, glycine, and glutamate — help bind free radicals and toxins. Then it can move them safely and effectively out of your system.

Your body produces some level of glutathione naturally. However, a poor diet, exposure to toxins, medications, stress, and illness deplete your levels or stop glutathione synthesis altogether. Glutathione deficiency factors into oxidative stress as well as triggering your body’s inflammatory response.

And we know that autoimmune diseases including rheumatoid arthritis, Crohn’s disease, and multiple sclerosis are often the result of chronic inflammation.1 Without enough glutathione, your body cannot properly detox. Toxins linger in your bloodstream or get stored in fat. This wreaks havoc on your immune system and sets you up for chronic illness.

Glutathione Is A Top Autoimmune Supplement

When I recommend supplements for autoimmune disease, glutathione is at the top of my list for those with heavy metal overload, mold exposure, or general toxin exposure. It’s so powerful that I recommend increasing supplemental glutathione levels to anyone who wants to take back their health. However, I tried a LOT of different types of glutathione, especially when I dealt with mold exposure. It is very challenging to get a form of glutathione that actually works!

Glutathione Sources

Intravenous (IV) glutathione supplementation is the gold standard. Yet it’s expensive and inconvenient. Oral glutathione supplementation is more readily available, however, it’s not commonly found in the liposomal or acetylated form. That means most will break down before your body can use them.

The “liposomal” form of glutathione is in a fat-soluble membrane that helps protect it from breaking down in the gut so it can effectively penetrate your cell walls. However, after working with thousands of patients, I recommend the “acetylated” form over all others. Your body easily absorbs it without breaking it down. Adding an acetyl group makes the glutathione molecule more stable and enhances its ability to cross the blood-brain barrier.2

The glutathione I offer is acetylated, making it even more readily used by your body than other acetylated forms. The acetylation process and microcluster molecular structure ensure that it won’t break down before your body absorbs it so you can enjoy all the health benefits of this autoimmune supplement.

Glutathione As An Autoimmune Supplement

Chronic inflammation can increase oxidative stress, which is an imbalance of free radicals and antioxidants at a cellular level. When there are more free radicals than antioxidants, the free radicals can start doing damage to your cells, protein, and DNA. Over a long period of time, this damage can lead to numerous diseases, including autoimmunity.

Glutathione is the body’s ultimate free radical scavenger. It also helps the body process and eliminate other toxins such as heavy metals that contribute to inflammation and autoimmunity. For that very reason, it’s important to have optimal levels of glutathione to support a healthy inflammatory response.

2. Curcumin

There’s a lot of hype around curcumin these days, and for good reason! Curcumin comes from a highly concentrated extract of turmeric. It plays an important role in supporting a healthy inflammatory response, a healthy immune system, and healthy aging without the gut-damaging side effects of popular over-the-counter remedies. It can positively impact the expression of genes that regulate systemic inflammation, making it a great supplement for autoimmune disease.3

Similar to glutathione, even high-grade curcumin supplements are generally not well absorbed in your gut, and often metabolized by your liver before ever being utilized. That’s why I recommend a liposomal form of curcumin. Since curcumin is fat soluble, taking it in liposomal form provides your body with the lipids curcumin needs in order to enhance bioavailability.

A micelle formula of liposomal curcumin is the world’s most absorbable form of curcumin. What is a micelle? It’s a fat pocket. Liposomal Curcumin solves the problem of poor absorption by coating the curcumin with a thin layer of fat from medium-chain-triglyceride (MCT) oil.

Your intestinal lining readily absorbs the micelle “pocket” created by MCT oil which protects it from metabolism by your liver. This way, the potent, 500mg of naturally extracted curcumin per serving can travel freely throughout your body to the cells and tissues that need it the most.

Curcumin As An Autoimmune Supplement

Research shows that curcumin is one of the most powerful free-radical fighters in the world. As I mentioned above, free radicals can cause systemic inflammation throughout the body, which can over-activate the immune system and potentially lead to immune dysfunction. Eliminating free radicals with the help of an autoimmune supplement such as curcumin is critical to support healthy immune function.

3. Resveratrol

Resveratrol is a polyphenol commonly found in red wine, however supplemental forms are more potent. It’s known for its ability to support healthy aging and its effect on metabolism.

Resveratrol can also support heart health, which is essential because people with autoimmunity are more susceptible to heart disease. In fact, one study shows that women aged 35 – 44 who have lupus are 50 times more likely to have a heart attack than other women of similar age.4

Resveratrol helps protect the innermost layer of your arteries called your endothelium, and increases your endothelial production of nitric oxide, supporting balanced blood pressure. You can get all of the health effects of this autoimmune supplement without the downsides of red wine such as sugar, alcohol, sulfites, and histamines by taking a resveratrol supplement.

Resveratrol As An Autoimmune Supplement

Research has shown that resveratrol can support your body’s immune function and inflammatory response.

Resveratrol is a great autoimmune supplement because it helps modulate your immune system by regulating the activity of a kind of white blood cells called natural killer cells. This helps balance your immune response if your immune system is overactive or suppressed.5

4. L-Glutamine

The last autoimmune supplement I recommend is L-Glutamine. L-Glutamine is an amino acid that helps seal the tight junctions in your gut. Your gut cells naturally turn over every 48 hours, which is why it’s possible to repair your gut in 30 days following The Myers Way®. L-Glutamine works by speeding up that process and helping to restore your gut lining if you have a leaky gut.

As I outline in my book, The Autoimmune Solution, repairing your gut is the first step to overcoming autoimmunity. Remember, nearly 80% of your immune system lives in your gut. Maintaining a healthy gut is key for anyone with an autoimmune condition. It’s why I always say the gut is the gateway to health!

In addition to promoting optimal gut health, L-Glutamine supplements support thyroid and immune system function. L-Glutamine also tames sugar cravings and supports healthy weight maintenance.

L-Glutamine As An Autoimmune Supplement

Supporting your gut barrier integrity is critical to promote optimal immune function. When you have a compromised gut barrier, many inflammatory proteins can leak out into your bloodstream and trigger immune responses that can damage your cells. L-Glutamine is a great supplement for autoimmune disease as it can help repair the damage caused by leaky gut.

Curious to see if any of these products end up on your personalized supplements list? Take this quiz to find out!

Support Your Immune System With Autoimmune Supplements

As I explain in The Autoimmune Solution, if you are dealing with autoimmunity, the source of your condition is a glitch in your immune system. Environmental risk factors such as diet, a leaky gut, toxins, infections, and stress lead your immune system to attack your own tissues.

It could be your thyroid being attacked, or your joints under fire, or symptoms associated with your skin. No matter what particular organ or tissue is attacked, your immune system is doing the firing. By supporting rather than suppressing your immune system with the help of autoimmune supplements, you are able to eliminate symptoms and reverse your condition.

Your Opportunity To Take Back Your Health

The Myers Way® Autoimmune Kit is a combination of the four most important nutritional supplements for autoimmune disease. Your immune system is a complex puzzle influenced by many aspects of health. The integrity of your gut barrier, oxidative damage done by free radicals, toxic load and detoxification, inflammation, and much more all play a role in how your immune system functions. My essentials kit is a carefully selected combination of four best natural supplements for autoimmune disease I recommend to anyone concerned about maintaining a healthy and balanced immune response in the face of an increasingly stressful and toxic environment.

Do you think you have autoimmunity? Take this short quiz to determine if autoimmunity could be at the root of your symptoms.

The Myers Way® Autoimmune Kit is perfect for anyone who:

  • Is concerned with immune system function and autoimmunity
  • Is dealing with systemic inflammation
  • Has had toxic exposures in the past or presently
  • Wants to support healthy thyroid function
  • Is seeking an autoimmune natural treatment

I myself have suffered from and overcome autoimmunity and I’ve worked with thousands of patients in my clinic to reverse their autoimmunity with the help of autoimmune supplements. Ultimately, when you have an autoimmune disease, your best course of action is to support your immune system and help it do the work that will keep you healthy. These autoimmune supplements are just a starting point on your journey to health and wellness!

Physician-formulated to tackle autoimmunity from every angle. Get your AI Kit now!

The 4 Best Autoimmune Supplements FAQs


What are the best natural supplements for autoimmune disease?

The top 4 physician-formulated autoimmune supplements I recommend to support a healthy immune response are Glutathione, Curcumin, Resveratrol, and L-Glutamine.


How can I boost my immune system to prevent and reverse autoimmune disease?

You can maintain a healthy and balanced immune response by supporting the integrity of your gut barrier, reversing oxidative damage done by free radicals, reducing your toxic exposure, and addressing infections that may be contributing to inflammation.


Can you reverse autoimmune disease naturally?

Rather than suppressing your immune system, taking supplements for autoimmune disease such as those found in The Myers Way® Autoimmune Kit can promote a healthy immune response.

Article Sources

  1. Glutathione Dysregulation and The Etiology and Progression of Human Diseases. Nazzareno Ballatori, Suzanne M Krance, Sylvia Notenboom, Shujie Shi, Kim Tieu, Christine L Hammond. NCBI. 2009.
  2. Types of Glutathione. Glutathione Pathway.
  3. Efficacy of Tumeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clincial Trials. James W Daily, Mini Yang, Sunmin Park. NCBI. 2016.
  4. The Increased Cardiovascular Risk in Patients Affected by Autoimmune Diseases: Review of the Various Manifestations. Alessandro Durante, Sofia Bronzato. NCBI. 2015.
  5. Resveratrol Role in Autoimmune Disease - A Mini-Review. Ana Ligia de Brito Oliveira, Valter Vinicius Silva Monteiro, Kely Campos Navagantes-Lima, Jordano Ferriera Reis, Rafaelli de Souza Gomes, Davila Valentina Silva Rodrigues, Silvia Leticia de Franca Gaspar, Marta Chagas Monteiro. NCBI. 2017.